Volumineux Mélanome Malin De La Conjonctive Multi Récidivant À Propos d’un Cas

Melanoma of the conjunctiva is a tumor that develops from the conjunctival melenocytes. It often reoccurs even after several surgical removals. The authors present the case of a 45 years old woman who was at first seen in our outpatient clinic with a spitz naevus of the conjunctiva of the right eye since more than 20 years ago. This naevus which was excised twice and then the eye enucleated underwent malignant transformation into a voluminous multi-recidivant malignant melanoma weighing after surgical removal 350g and measures 6x12x5cm

Modèle de régression optimale des traits de conformation et de la production laitière des troupeaux bovins de race kouri élevés à la station de Sayam du Niger.

Objectif : évaluer en station, la pertinence des traits de conformation traditionnellement privilégiés par les éleveurs kouri, pour l’identification des meilleures vaches laitières.Méthodologie et résultats : La production laitière et treize traits biométriques ont été évalués sur 54 vaches, de septembre 2015 à février 2016, au Centre de Multiplication de Bétail de Sayam, après six (6) mois de contrôle laitier. Il est constaté que la production laitière journalière était positivement corrélée aux traits de conformation du bassin (largeur aux ischions (r = 0.35**) et la largeur aux trochanters (r = 0.36**)), à la profondeur de poitrine (r = 0.27*), à la largeur aux poitrines (r = 0.29*) et au rapport de la largeur aux poitrines sur la largeur aux hanches (r = 0.28*). Le modèle de régression optimale de la production laitière qui s’est bien ajusté de façon hautement significative (p = 0.004) est un modèle utilisant la largeur-Trochanters et le rapport largeur- Poitrine/Largeur-hanche comme indices prévisionnels. La valeur du R carrée ajusté du modèle et de l’erreur standard des résidus étaient respectivement 0.16 et 0.43.Conclusion et perspectives : les traits biométriques intéressants, identifiés comme promoteurs dans cette étude, peuvent être inclus dans le développement de mécanismes de sélection qui peut encore être couplé à des techniques modernes de sélection. Le modèle ainsi obtenu, pourrait être utilisé pour prédire la production de lait des vaches kouri ou à des fins de sélection.Mots clés : Corrélation, modélisation, traits de conformation, production laitière, kour

La migraine en milieu scolaire a Gao ua Mali

Introduction La migraine est une maladie bénigne mais handicapante et qui peut altérer la qualité de vie des patients, perturber les relations affectives et retentir sur les activités scolaires et professionnelles. Objectifs L’objectif de notre travail était d’étudier les aspects épidémiologiques et l’impact de la migraine en milieu scolaire dans la commune urbaine de Gao au Mali. Méthodes Il s’agit d’une étude transversale réalisée chez les élèves de la ville de Gao. Le sondage a été fait par grappes dans 11 lycées dont chacun a représenté une grappe. L’étude a porté sur 733 élèves le diagnostic de migraine était retenu suivant les critères de L’International Headache Society (IHS) IHS 2004 et le GRIM. Résultats La prévalence globale de la migraine en milieu scolaire était de 17,3% (IC95% : [14,6% à 20%]). La prévalence parmi les élèves céphalalgiques était de 20%(IC95% : [16,91% à 23,09]), elle était significativement plus élevée chez les filles 23,0% que chez les garçons 14,8% (p< 0,01). Concernant son impact sur la vie scolaire, 63,8% des élèves migraineux avaient un absentéisme de 1 à 14 jours avec une moyenne de 5 jours pendant le dernier trimestre précédant l’enquête ; il y avait une limitation de la concentration chez 19,2% des élèves migraineux.Conclusion La migraine est fréquente chez les lycéens de Gao avec une prédominance féminine. Elle a un impact négatif sur le rendement scolaire du à l’absentéisme et aux troubles de la concentration. Il apparait donc important de procéder à une campagne de sensibilisation ciblée à grande échelle dans l’environnement scolaire

Uncertain pasts and risk-sensitive futures in sub-Saharan urban transformation

This chapter explores the status and the scope for transition of risk- sensitive and transformative urban development in diverse cities of sub-Saharan Africa. Sub-Saharan Africa is important because of its large proportions of urban populations with high vulnerability and growing exposure to risks. High rates of urban growth pose increasing risks as we go into the future, yet there is also opportunity to reduce risk through integrating risk management into development. However, this opportunity space is often constrained by limited capacities to plan and manage the rapid urbanisation process, particularly in informal settlements. Limited capacities to prevent processes of risk accumulation pose threats to poverty reduction and sustainable development. In this context, there is an increasingly urgent need for squarely recognising and addressing the underlying vulnerabilities of urban populations and their root causes. Transitioning towards such sustainable urban pathways will require the strengthening of capacities and accountability of city authorities and broader governance systems, both formal and informal

A Positive Correlation between Atypical Memory B Cells and Plasmodium falciparum Transmission Intensity in Cross-Sectional Studies in Peru and Mali

transmission intensity correlates with atypical memory B cell expansion.. In Peru, the mean level of atypical memory B cells, as a percent of total B cells, was higher than U.S. adults (Peru mean: 5.4% [95% CI: 3.61–7.28]; U.S. mean: 1.4% [95% CI: 0.92–1.81]; p<0.0001) but lower than Malian adults (Mali mean 13.1% [95% CI: 10.68–15.57]; p = 0.0001). In Peru, individuals self-reporting ≥1 prior malaria episodes had a higher percentage of atypical memory B cells compared to those reporting no prior episodes (≥1 prior episodes mean: 6.6% [95% CI: 4.09–9.11]; no prior episodes mean: 3.1% [95% CI: 1.52–4.73]; p = 0.028). infection could contribute to our understanding of naturally-acquired malaria immunity

Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali

<p>Abstract</p> <p>Background</p> <p>Malaria is a major public health problem in Mali and diagnosis is typically based on microscopy. Microscopy requires a well trained technician, a reliable power source, a functioning microscope and adequate supplies. The scarcity of resources of community health centres (CHC) does not allow for such a significant investment in only one aspect of malaria control. In this context, Rapid Diagnostic Tests (RDTs) may improve case management particularly in remote areas.</p> <p>Methods</p> <p>This multicentre study included 725 patients simultaneously screened with OptiMal-IT test and thick smears for malaria parasite detection. While evaluating the therapeutic efficacy of choroquine in 2 study sites, we compared the diagnostic values of thick smear microscopy to OptiMal-IT test applying the WHO 14 days follow-up scheme using samples collected from 344 patients.</p> <p>Results</p> <p>The sensitivity and the specificity of OptiMal-IT compared to thick smear was 97.2% and 95.4%, whereas the positive and negative predictive values were 96.7 and 96.1%, respectively. The percent agreement between the two diagnostic tests was 0.93. The two tests were comparable in detecting malaria at day 0, day 3 and day 14. The only difference was observed at day 7 due to high gametocytemia. Subjectively, health care providers found OptiMal-IT easier to use and store under field conditions.</p> <p>Conclusion</p> <p>OptiMal-IT test revealed similar results when compared to microscopy which is considered the gold standard for malaria diagnostics. The test was found to have a short processing time and was easier to use. These advantages may improve malaria case management by providing a diagnostic and drug efficacy follow-up tool to peripheral health centres with limited resources.</p

Mechanisms of adaptation to climate variability in West African pearl millet landraces – a preliminary

Landraces are generally expected to possess specific mechanisms of adaptation to their growing environments. In West and Central Africa (WCA), growing conditions of pearl millet (Pennisetum glaucum) are characterized, among other hazards, by highly variable beginnings and endings of the rainy season, and unpredictable drought stress at any time during the growing season. Adaptation to such unpredictable variable environment can be due to individual and/or populational buffering (Allard and Bradshaw 1964), two mechanisms initially defined by Lerner (1954) as developmental and genetic homeostasis. Individual buffering may be favored by phenotypic plasticity. Photoperiod-sensitive flowering is an example of phenotypic plasticity that can enhance adaptation to variable planting dates followed due to a scattered beginning of the rainy season in a region, as typical for WCA. It enhances simultaneous flowering of the cultivar in the target region, independent of the individual date of planting in different fields. This has particular advantages in terms of reducing bird damage and insect pressure; prolonging vegetative development in case of early planting but accelerating development in case of late planting; therefore fitting plant development to available rainfall patterns and resulting potentially in increased yielding stability. Populational buffering can be promoted by genetic heterogeneity in plant stand as different genotypes present in the population are specifically adapted to different environmental conditions (Bradshaw 1965). An example is intra-varietal variation for flowering time, which would assure that in case of a dry spell, not all plants in the field will be affected by drought in their most sensitive flowering stage

Towards risk-sensitive and transformative urban development in sub Saharan Africa

Risk-sensitive urban development is required to reduce accumulated risk and to better consider risk when planning new developments. To deliver a sustainable city for all requires a more frank and comprehensive focus on procedure: On who makes decisions, under which frameworks, based upon what kind of data or knowledge, and with what degree and direction of accountability? Acting on these procedural questions is the promise of transformative urban development. This paper explores the status of risk sensitive and transformative urban development and the scope for transition towards these components of sustainability in urban sub-Saharan Africa through the lens of diverse city cases: Karonga (Malawi), Ibadan (Nigeria), Niamey (Niger) and Nairobi (Kenya). The paper draws from a 3-year research and capacity building programme called Urban Africa: Risk Knowledge that aims to address gaps in data, understandings and capacity to break cycles of risk accumulation. A common analytical framework is presented to help identify blockages and opportunities for transition towards a risk-sensitive and transformative urban development. This framework is then illustrated through each city in turn and a concluding discussion reflects on city observations to draw out recommendations for city level and wider action and research partnerships

Health facility-based prevalence and potential risk factors of autism spectrum disorders in Mali

Background: The prevalence of autism spectrum disorders (ASD) is 1-2% worldwide, 1 in 68 in the U.S, and unknown in Africa. ASD is under-diagnosed in Mali due to stigma and the lack of appropriate human resources and infrastructure.Objective: To determine the ASD frequency and potential risk factors in Mali.Methods: We identified all the health facilities and community-based organizations involved in the ASD diagnosis and management in Bamako. We established an ASD research and awareness platform in Mali, which encompasses community-based organizations and a multidisciplinary team including psychiatrists, psychologists, pediatricians, geneticists, and public health and social science specialists. Through this platform, we performed a survey in health facilities and organizations where patients with ASD are likely to seek care in Bamako. We reviewed the psychiatric patient registry to obtain basic epidemiological profiles of children with ASD, epilepsy and other psychiatric disorders.Results: We found a health facility-based prevalence of ASD of 4.5% (105/2,343) in Bamako. The mean age at the first outpatient visit was 7.64 ± 3.85 years old. First degree consanguinity of 29.5% (31/105) was more frequent in parents of ASD children versus age and sex matched controls OR= 4.37 [1.96-9.76] p=0.0001.Conclusion: Our data suggest that ASD is more common than expected in Mali. The established ASD awareness and research platform may improve the diagnosis and management of ASD by raising ASD awareness, training of Malian clinicians and researchers in early ASD screening and diagnosis, and strengthening research capacity in genomics of ASD and other mental disorders.Keywords: ASD, prevalence, consanguinity, health facilit